Problem:

Is it possible to change the default Win2PDF printer settings such as paper size for a large number of users from a script?

Solution:

The following knowledgebase article from Microsoft describes a command line tool for modifying printer settings:
http://support.microsoft.com/kb/189105

 

If you type the following command, it will save the current printer settings for the Win2PDF printer to a file named "file.dat":

rundll32 printui.dll,PrintUIEntry /Ss /n "Win2PDF" /a "file.dat" u

You can restore the settings using the following command:

rundll32 printui.dll,PrintUIEntry /Sr /n "Win2PDF" /a "file.dat" u

After you have changed the Win2PDF printer settings to the desired settings, you can use these commands to save the settings to a file and then write a script to restore the saved printer settings for other users.